李瑞宾，特聘教授、博士生导师
电话：0512-65880062
电子邮箱：liruibin@suda.edu.cn
通讯地址：苏州工业园区仁爱路199号, 邮编215123
李瑞宾，苏州大学放射医学与辐射防护国家重点实验室教授、博士生导师，主要从事类酶功能材料的设计，催化生物学机制探索及催化药物的应用研究。发表SCI论文100多篇，全部论文谷歌引用8900余次，H指数49。发表通讯作者论文40多篇（一区, 35篇），包括Nat Nanotech (1篇), Nat. Commun. (6篇), Angew. Chem.-Int. Ed. (5篇), J. Am. Chem. Soc. (2篇), PNAS (1篇)，Environ. Health Perspect. (1篇)等。申请发明专利9项，国际专利2项，已授权6项。主持研发的细胞活性检测设备与试剂盒获批4项I类医疗器械，已开展市场销售。建立的纳米颗粒放射标记动物体内检测方法获得国家标准立项，提名ISO国际标准PWI项目。主持国家级科技项目4项，科技部重点研发政府间创新合作项目，基金委面上项目。主持省部级科技项目5项，包括江苏省“双创团队”、“杰出青年科学基金”、江西省“双千计划”等。入选ELSEVIER“中国高被引学者”，受邀担任ELSEVIER旗下NanoImpact期刊（IF：5.3）副主编，中国毒理学会纳米毒理学专业委员会、中国生物物理学会纳米酶专业委员会委员，国际标准委员会（ISO）TC229工作组注册专家。
研究方向：
催化医学
1、类酶催化新材料的设计与制备
2、免疫响应及代谢功能的催化调控机制探索
3、针对肿瘤转移、衰老、细菌感染的催化药物开发
基金项目：
2023年，苏州医学院“杰青”培育项目，100万，项目主持
2021年，江苏省杰出青年项目，100万，项目主持；
2020年，江苏省“双创团队”领军人才，300万，项目主持；
2020年，江西省创业“双千计划”，500万，项目主持；
2020年，科技部重点研发计划变革性关键科学问题，80万，参与；
2020年，国家科技部国际合作重点专项，103万，项目主持；
2019年，国家基金委面上项目，65万，项目主持；
2018年，江苏省社会发展重点项目，200万，项目主持；
2017年，江苏省“双创人才计划”；50万，项目主持；
2017年，江苏省高等学校自然科学研究重大项目, 30万,项目主持;
2016年，国家自然科学基金委面上项目，62万，项目主持；
2016年，国家青年项目，300万，项目主持
专利：
1.青蒿琥酯在制备防治贫血药物中的应用，2025，申请号：2025110865171
2.一种有机金属大环化合物分子在催化提升细胞内氧化型辅酶I水平、抗衰老产品中的应用，2025，申请号：PCT2510006
3. Identification and optimization of carbon radicals on hydrated graphene oxides for ubiquitous antibacterial coatings, 2016,授权号：US 2020/0270134 A1
4.一种二苯基二硒的制备方法, 2021，授权号：CN 119552103 B
5.一种含过氧化物脂质体及其制备方法与应用，2024，CN 118986887 B
6.一种肺表面活性剂氧化效应的评价方法，2021，授权号：CN 113433271 B
7.含有Zn-N-C活性中心的纳米材料在去除细菌生物膜中的应用，2022，授权号：CN 115532295 B
8.红外II区荧光金纳米团簇及其制备与应用，2020，授权号：CN 11849467 B
9.一种二维纳米材料作为脱氢酶的应用，2019， 授权号：CN 110702675 B
10.生物组织活细胞分离器，2019， 授权号：CN 209778876 B
代表性学术论文：
1、Jiang J, Zheng H, Wang Z, Wang X, Xie Q, Liu X, Yang Q, Cai X, Gao X,Li R*, Chen C*, Intracellular dehydrogenation catalysis leads to reductive stress and immunosuppression,Nat. Nanotech. 2025, 554-562.
2、Yang, Q. Chen D, Liu X, Li W, Zheng Z, Cai X*,Li R* Identification of Nanoparticle Infiltration in Human Breast Milk: Chemical Profiles and Trajectory Pathways.Proc. Natl. Acad. Sci. USA. 2025, e2500552122.
3、Huang Y, Cao J, Li X*, Yang Q, Xie Q, Liu X, Cai X*, Chen J, Hong H,Li R*, Multimodal Feature Fusion Machine Learning for Predicting Chronic Injury Induced by Engineered Nanomaterials,Nat. Commun. 2025, 2765.
4、Tian M, Wu D, Gou X,Li R*, Zhang X*, Genetic Modulation of Rare Earth Nanoparticle Biotransformation Shapes Biological Outcomes,Nat. Commun. 2025, 3429.
5、Jiang J, Yang L, Xie Q, Liu X, Jiang J, Zhang J, Zhang S, Zheng H, Li W, Cai X, Liu S*,Li R*, Synthetic Vectors for Activating the Driving Axis of Ferroptosis,Nat. Commun. 2024, 7923.
6、Wang W, Zheng W, Jiang J, Li Z, Jiang D, Shi X, Wang H, Jiang J, Xie X, Gao M, Chu J, Cai X, Xia X,Li R*Engineering Micro Oxygen Factories to Slow Tumour Progression via Hyperoxic Microenvironments,Nat. Commun. 2022, 4495.
7、Xu, S.; Zheng, H.; Ma, R.; Wu, D.; Pan, Y.; Yin, C.; Gao, M.; Wang, W.; Li, W.; Liu, S.; Chai, Z.;Li, R.*,Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death,Nat. Commun. 2020, 11, 3484.
8、Cai, X.; Dong, J.; Liu, J.; Zheng, H.; Kaweeteerawat, C.; Wang F., Ji Z.*;Li, R.*, Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces,Nat. Commun. 2018, 9, 4416.
9、Jiang J; Wang W; Zheng Z; Chen X; Liu X; Xie Q; Cai X; Zhang Z;Li R*Nano-enabled photosynthesis in tumours to activate lipid peroxidation for overcoming cancer resistances,Biomaterials2022, 121561.
10、Liu X, Li J, Zitolo A, Gao M, Jiang J, Geng X, Xie Q, Wu D, Zheng H, Cai X, Lu J, Jaouen F,Li R* Doped Graphene To Mimic the Bacterial NADH Oxidase for One-Step NAD+ Supplementation in Mammals,J. Am. Soc. Chem. 2023, 3108-3120.
11、Wu, D.; Li, J.; Xu, S.; Xie, Q.; Pan, Y.; Liu, X.; Ma, R.; Zheng, H.; Gao, M.; Wang, W.; Li, J.; Cai, X.; Jaouen, F.*;Li, R.*, Engineering Fe-N Doped Graphene to Mimic Biological Functions of NADPH Oxidase in Cells,J. Am. Chem. Soc., 2020, 19602.
12、Liu X, Gao M, Qin Y, Xiong Z, Zheng H, Willner I, Cai X*,Li R*, Exploring Nanozymes for Organic Substrates: Building Nano-organelles,Angew. Chem.-Int. Ed. 2024, e202408277.
13、Xie M, Gao M, Yun Y, Malmsten M, Rotello VM, Zboril R, Akhavan O, Kraskouski A, Amalraj J, Cai X, Lu J, Zheng H,Li R*, Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles,Angew. Chem.-Int. Ed. 2023, e202217345.
14、Gao M, Xu B, Huang Y, Cao J, Yang L, Liu X, Djumaev, A,Wu D, Shoxiddinova M, Cai X, Tojiyev B, Zheng H, Li X, Normurodova K, Liu H*,Li R* Nano-enabled Quenching of Bacterial Communications for the Prevention of Biofilm Formation,Angew. Chem.-Int. Ed. 2023, e202305485.
15、Gao, M.; Wang, Z.; Zheng, H.; Wang, L.; Xu, X.; Liu, X.; Li, W.; Pan, Y.; Wang, W.; Cai, X.; Wu, R.; Gao, X.*;Li, R.*, Two-Dimensional Tin Selenide (SnSe) Nanosheets Capable of Mimicking Key Dehydrogenases in Cellular Metabolism,Angew. Chem.-Int. Ed. 2020, 132, 3618-3623.
16、Wang, W.; Kong, Y.; Jiang, J.; Xie, Q; Huang, Y.; Li, G.; Wu, D.; Zheng, H.; Gao, M.; Xu S.; Pan, Y.; Li, W.; Ma, R.; Li, X.; Zuilhof, Z.; Cai, C.;Li, R.*, Engineering the Protein Corona Structure on Gold Nanoclusters Enables Red‐Shifted Emissions in the Second Near‐infrared Window for Gastrointestinal Imaging,Angew. Chem.-Int. Ed.2020, 22431.
17、Huang, Y.; Li, X*.; Xu, S.; Zheng, H.; Zhang, L.; Chen, J.; Hong, H.; Kusko, R.;Li, R.*, Quantitative Structure–Activity Relationship Models for Predicting Inflammatory Potential of Metal Oxide Nanoparticles,Environ. Health Perspect.2020, 128, 067010.
18、Sun R, Cui Y, Wu Y, Gao M, Xue S,Li R*, Zbořil R*, Zhang C*, Overcoming Nanosilver Resistance: Resensitizing Bacteria and Targeting Evolutionary Mechanisms,ACS Nano 2025, 1702-1712.
19、Xie Q, Li W, Chen C, Yang Q, Jiang J, Cai X,Li R*, Discovery of Lipoxygenase-Like Materials for Inducing Ferroptosis,ACS Nano 2024, 32438-32450.
20、Pan, Y; Zheng, H; Li, G; Li, Y; Jiang, J; Chen, J; Xie, Q; Wu, D; Ma, R; Liu, X; Xu, S; Jiang, J; Cai, X; Gao, M; Wang, W; Zuilhof, H; Ye, Y*; Li R* Antibiotic-Like Activity of Atomic Layer Boron Nitride for Combating Resistant Bacteria, ACS Nano 2022, 7674.
21、Zheng, H.; Ji, Z.; Roy, K.; Gao, M.; Pan, X.; Cai, X.; Wang, L.; Li, W.; Chang, C.; Kaweeteerawat, C.; Chen, C.; Xia, T.; Zhao, Y.;Li, R.*, Engineered graphene oxide nanocomposite capable of preventing the evolution of antimicrobial resistance,ACS Nano, 2019, 11488.
22、Li W, Panacek D, Xie Q, Chen H, Yang Q, Xie M, Wu D, Cai X, Dědek I, Zhang Z,* Zboril R,*Li R*, Precision Fishing for Enzyme-like Materials: Identifying and Engineering Mesoporous Catalytic Sites for Ferroptosis Induction,Nano Letter 2025, 11356-11364.
23、Gao M., Liu X., Wang Z., Wang H., Assetc T., Wu D., Jiang J., Xie Q., Xu S., Cai X., Li J., Wang W., Zheng Z., Gao X., Tarasenkoe N., Rotonnellif, B., Galletg, J., Jaouenc F.,Li, R.*Engineering catalytic dephosphorylation reaction for endotoxin inactivation,Nano Today 2022, 101456.
24、Xie M, Jiang J, Xiong Z, Zhang D, Chen H, Shen S, Okoh A, Gao M, Zheng H*,Li R*, Impacts of Environmental Pollutants on Antimicrobial Resistance Gene Transfer: A Comparative Analysis,Environ. Sci. Technol. 2025, 26350–26361.
25、Gao M, Chen J, Chen C, Xie M, Xie Q, Li W, Jiang J, Liu X, Cai X, Zheng H, Zhang C*,Li R*, Nano-microflora Interaction Inducing Pulmonary Inflammation by Pyroptosis,Environ. Sci. Technol. 2024, 8643-8653.
26、Yang L, Cai X,Li R*, Ferroptosis induced by pollutants: an emerging mechanism in environmental toxicology,Environ. Sci. Technol. 2024, 8643-8653.
27、Wang H, Wang W, Xie Q, Wu D, Cao J, Chen H, Gao M, Zheng H, Liu X, Jiang J, Li W, Cai X, Gudkov SV,Li R* Using Chicken Embryos to Identify the Key Determinants of Nanoparticles for the Crossing of Air–Blood Barriers,Anal. Chem.2023, 6009.
28、H Zheng, Y Huang, J Jiang, Y Pan, W Li, H Wang, L Su, X Liu, M Gao, W Wang, J Li, X Cai, X Li*, J Chen,R Li*, Lighting Nanoscale Insulator by Steric Restriction Induced Emissions,Anal. Chem. 2022, 12060.
29、Cao J, Yang Y, Liu X, Huang Y, Xie Q, Kadushkin A, Nedelko M, Wu D, Aquilina NJ, Li X, Cai X*,Li R*, Deciphering key nano-bio interface descriptors to predict nanoparticle-induced lung fibrosis, Part. Fibre Toxic. 2025, 22, 1.
30、Cao J. Yang Q.; Jiang J.; Dalu T.; Kadushkin A.; Singh J.; Fakhrullin R.; Wang F.; Cai X.*;Li R.* Coronas of micro/nano plastics: a key determinant in their risk assessments,Part. Fibre Toxicol.2022, 19:55.
31、Zheng, H.; Gu, Z.; Pan, Y.; Chen, J.; Xie, Q.; Xu, S.; Gao, M.; Cai, X.; Liu, S.; Wang, W.; Liu, X.; Yang, Z.*; Zhou, R.;Li, R.* Biotransformation of rare earth oxide nanoparticles eliciting microbiota imbalance,Part. Fibre Toxicol. 2021, 18:1.
32、Cai, X.; Lee, A.; Ji, Z.; Huang, C.; Chang, C. H.; Wang, X.; Liao, Y.-P.; Xia, T.*;Li, R.*, Reduction of pulmonary toxicity of metal oxide nanoparticles by phosphonate-based surface passivation.Part. Fibre Toxicol.2017,14：13.
33、Zheng, H.; Jiang, J.; Xu, S.; Liu, W.; Xie, Q.; Cai, X.; Zhang, J.; Liu, S.;Li, R.*, Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications,Nanoscale2021, 59, 2266-2285.
34、Cai, X.; Liu, X.; Jiang, J.; Gao, M.; Wang, W.; Zheng, H.; Xu, S.;Li, R.*, Molecular Mechanisms, Characterization methods and Utilities of Nanoparticle Biotransformation in Nanosafety Assessments,Small, 2020, 1907663.
35、Zheng, H.; Ma, R.; Gao, M.; Tian, X.; Li, Y.; Zeng, L.*;Li, R.*, Antibacterial applications of graphene oxides: structure-activity relationships, molecular initiating events and biosafety,Sci. Bull. 2018, 133.
36、Chen H, Xie M, Li W, Tan L, Cai X, Shen M*,Li R*, Detection of 6-PPD and 6-PPDQ in airborne particulates and assessment of their toxicity in lung cells,Chemosphere 2024, 143205.
37、Ma, R.; Cai, X.; Zhou, Y.; Liu, X.; Wu, D.; Zheng, H.; Pan, Y.; Jiang, J.; Xu, S.; Xie, Jie Jiang, Q.; Wang, W.; Tarasenko, N.; Wang, F.*;Li, R* Emerging investigator series: long-term exposure of amorphous silica nanoparticles disrupts the lysosomal and cholesterol homeostasis in macrophages,Evironment. Sci: Nano 2022, 105-117.
38、Li, R.; Guiney, L.; Chang, C.; Mansukhani, N.; Ji, Z.; Wang, X.; Liao, Y.; Jiang, W.; Sun, B.; Hersam, M. Nel, A.*; Xia, T.*, Surface oxidation of graphene oxide determines membrane damage, lipid peroxidation, and cytotoxicity in macrophages in a pulmonary toxicity model,ACS Nano, 2018, 1390.
39、Li, R., Guiney, L.M., Chang, C., Mansukhani, N.D., Ji, Z., Wang, X., Liao, Y., Jiang, W., Sun, B., Hersam, M.C., Nel, A.E., Xia, T.*, Surface oxidation of graphene oxide determines membrane damage, lipid peroxidation, and cytotoxicity in macrophages in a pulmonary toxicity model.ACS Nano2018, 12 (2): 1390-1402.
40、Li, R.; Mansukhani, N. D.; Guiney, L. M.; Ji, Z.; Zhao, Y.; Chang, C. H.; French, C. T.; Miller, J. F.; Hersam, M. C.; Nel, A. E.; Xia, T., Identification and Optimization of Carbon Radicals on Hydrated Graphene Oxide for Ubiquitous Antibacterial Coatings.ACS Nano2016,10 (12), 10966-10980.
41、Li, R.; Ji, Z.; Dong, J.; Chang, C. H.; Wang, X.; Sun, B.; Wang, M.; Liao, Y.-P.; Zink, J. I.; Nel, A. E.; Xia, T., Enhancing the Imaging and Biosafety of Upconversion Nanoparticles through Phosphonate Coating.ACS Nano2015,9 (3), 3293-3306.
42、Li, R.; Ji, Z.; Chang, C. H.; Dunphy, D. R.; Cai, X.; Meng, H.; Zhang, H.; Sun, B.; Wang, X.; Dong, J.; Lin, S.; Wang, M.; Liao, Y.-P.; Brinker, C. J.; Nel, A.; Xia, T., Surface Interactions with Compartmentalized Cellular Phosphates Explain Rare Earth Oxide Nanoparticle Hazard and Provide Opportunities for Safer Design.ACS Nano2014,8 (2), 1771-1783.
43、Li, R.; Ji, Z.; Qin, H.; Kang, X.; Sun, B.; Wang, M.; Chang, C. H.; Wang, X.; Zhang, H.; Zou, H.; Nel, A. E.; Xia, T., Interference in Autophagosome Fusion by Rare Earth Nanoparticles Disrupts Autophagic Flux and Regulation of an Interleukin-1 beta Producing Inflammasome.ACS Nano2014,8 (10), 10280-10292.
44、Li, R.; Wang, X.; Ji, Z.; Sun, B.; Zhang, H.; Chang, C. H.; Lin, S.; Meng, H.; Liao, Y.-P.; Wang, M.; Li, Z.; Hwang, A. A.; Song, T.-B.; Xu, R.; Yang, Y.; Zink, J. I.; Nel, A. E.; Xia, T.*, Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity.ACS Nano2013,7 (3), 2352-2368.
45、Li, R.; Wu, R. a.; Zhao, L.; Hu, Z.; Guo, S.; Pan, X.; Zou, H.*, Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells.Carbon2011,49 (5), 1797-1805.
46、Li, R.; Wu, R. a.; Zhao, L.; Wu, M.; Yang, L.; Zou, H.*, P-Glycoprotein Antibody Functionalized Carbon Nanotube Overcomes the Multidrug Resistance of Human Leukemia Cells.ACS Nano2010,4 (3), 1399-1408.