实验室副主任：高明远  杰青

教授、博士生导师

电话：0512-65883241 

电子邮箱：gaomy@iccas.ac.cn, gaomy@suda.edu.cn

通讯地址：苏州工业园区仁爱路199号，邮编：215123

个人简历：

1996年获得德国洪堡奖学金，2002年获国家杰出青年基金（化学部），2005年获得“XX计划”终期评估优秀奖，2006年起享受国务院政府津贴，2011年起任973项目首席科学家，2014 年获得北京市科学技术奖一等奖（第一完成人），2020年起任国家级重点领域创新团队负责人，国家“万人计划”科技创新领军人才，获教育部高等学校科学研究优秀成果奖（科学技术）一等奖（第一完成人），2022年获江苏省科学技术奖二等奖（第一完成人）。现任中国研究型医院学会肿瘤影像诊断学专业委员会常委，上海市分子影像学重点实验室、中国医学科学院医学影像研究中心、天津市功能影像重点实验室、江苏省分子影像与功能影像重点实验室、分子影像湖北省重点实验室学术委员会副主任及委员。先后主持国家重点研发专项项目1项，国家重点基础研究发展计划（973计划）项目1项，863项目2项，基金委化学部杰出青年基金项目1项，基金委医学部重大项目子课题1项，基金委医学部重点项目1项，基金委重大国际合作项目2项（化学部和医学部）。截至目前，在Chem. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., Nat. Comm., Biomaterials等学术期刊上共发表学术论文260+篇，累积引用26000+次。撰写中英文专著3章1部。组织境内外学术会议10+次，应邀参加学术会议做特邀及邀请报告220+次。目前，担任Current Pharmaceutical Design，Advanced Therapeutics等期刊的编辑或国际顾问编委。

研究方向：

1、重大疾病相关分子影像探针的设计与构建

2、疾病微环境异常因素定量成像

3、纳米材料与免疫系统的相互作用

4、先进的生物检测与疾病诊断技术

5、转化医学

科研项目：

1、百人计划，项目名称：无机纳米晶体的制备、性质与应用，2001-2004，主持，结题

2、863纳米专项，项目名称：无机纳米微粒及金属富勒烯在癌症检测和治疗中的应用，项目编号：2002AA302201，2002-2005，主持，结题

3、国家杰出青年科学基金，项目名称：荧光纳米微粒的制备、荧光性质研究及应用，项目编号：20225313，2003-2006，主持，结题

4、基金委重大国际合作项目，项目名称：纳米晶体与生物屏障的相互作用研究，项目编号：20820102035，2009-2012，主持，结题

5、基金委重大项目，项目名称：肿瘤多模态分子影像探针的构建及其在胃癌研究中的应用，项目编号：81090271，2011-2014，主持，结题

6、科技部“国家重点基础研究发展计划”（973），项目名称：多模态智能化纳米分子影像探针及其在结直肠癌诊断与研究中的应用，项目编号：2011CB935800，2011-2015，主持，结题

7、基金委重点项目，项目名称：面向胃癌高分辨成像与精准诊疗纳米探针的基础研究，项目编号：81530057，2016-2020，主持，结题

8、重点国际 (地区)合作研究项目，项目名称：针对纳米成像探针肿瘤靶向性探索纳米颗粒与蛋白的相互作用，项目编号：81720108024，2018-2022，主持，在研

9、国家重点研发计划，项目名称：新型纳米氧化铁磁共振造影剂的宏量制备及临床转化研究，项目编号：2018YFA0208800，2018-2023，主持，在研

10、基金委重点项目，项目名称：超小磁性氧化铁纳米多功能对比剂相关基础研究，项目编号：82130059，2022-2026，主持，在研

代表性论著：

1.Iron Homeostasis-Regulated Adaptive Metabolism of PEGylated Ultrasmall Iron Oxide Nanoparticles, Ning Wang, Dandan Zhou, Keyang Xu, Dandan Kou, Can Chen, Cang Li, Jianxian Ge, Lei Chen, Jianfeng Zeng*, Mingyuan Gao*, ACS Nano, 2025, DOI: 10.1021/acsnano.5c01399.

2.Splenic response to protein corona of nanoparticles in vivo, Can Chen, Yueping Li, Dandan Zhou, Jiada Fan, Xuelan Hu, Ruru Zhang, Jianxian Ge, Xiaoyi Cao, Haodi Qi, Ning Wang, Lei Chen, Baoxing Huang, Jianfeng Zeng*, Mingyuan Gao*, Nano Today, 2025, DOI: 10.1016/j.nantod.2025.102676.

3.Eliminating Radioresistance With a Magnetic Ion‐Generator by Simultaneously Augmenting DNA Damage and Diminishing Immunosuppression, Ruru Zhang, Mei Chen, Hui Zhou, Yan Liu, Yi Wang, Can Chen, Yueping Li, Jianfeng Zeng, Jiabin Cui*, Ruixue Duan*, Mingyuan Gao*, Adv. Mater., 2025, DOI: 10.1002/adma.202406378.,

4.PEGylated Ultrasmall Iron Oxide Nanoparticles as MRI Contrast Agents for Vascular Imaging and Real-Time Monitoring, Kuan Lu#, Ruru Zhang#, Hongzhao Wang, Cang Li, Zhe Yang, Keyang Xu, Xiaoyi Cao, Ning Wang, Wu Cai*, Jianfeng Zeng*, Mingyuan Gao*, ACS Nano, 2025, 19(3), 3519-3530.

5.Mechanotransduction-Piloted Whole-Cell Vaccines for Spatiotemporal Modulation of Postoperative Antitumor Immunity, Yuan Gu, Pei Xu, Yanxian Wu, Chenze Li, Jiahao Shen, Xiaju Cheng, Yangyun Wang, Leshuai W. Zhang, Yong Wang*, Mingyuan Gao*, ACS Nano, 2024, 18(42), 28675-28690.

6.Using Adaptive Imaging Parameters to Improve PEGylated Ultrasmall Iron Oxide Nanoparticles-Enhanced Magnetic Resonance Angiography, Cang Li#, Shanshan Shan#, Lei Chen, Mohammad Javad Afshari, Hongzhao Wang, Kuan Lu, Dandan Kou, Ning Wang, Yang Gao, Chunyi Liu, Jianfeng Zeng*, Feng Liu, Mingyuan Gao*, Adv. Sci., 2024, 11, 2405719.

7.Trapped in Endosome PEGylated Ultra-Small Iron Oxide Nanoparticles Enable Extraordinarily High MR Imaging Contrast for Hepatocellular Carcinomas, Dandan Zhou, Shanshan Shan, Lei Chen, Cang Li, Hongzhao Wang, Kuan Lu, Jianxian Ge, Ning Wang, Mohammad Javad Afshari, Yaqin Zhang*, Jianfeng Zeng*, Mingyuan Gao*, Adv. Sci., 2024, 11, 2401351.

8.Imaging and Downstaging Bladder Cancer with the 177Lu-Labeled Bioorthogonal Nanoprobe, Yueping Li#, Shanshan Shan#, Ruru Zhang, Chaoping Sun, Xuelan Hu, Jiada Fan, Yi Wang, Ruixue Duan*, Mingyuan Gao*, ACS Nano, 2024, 18(26), 17209-17217.

9.Radiotherapy-Triggered In Situ Tumor Vaccination Boosts Checkpoint Blockaded Immune Response via Antigen-Capturing Nanoadjuvants, Pei Xu, Jie Ma, Yang Zhou*, Yuan Gu, Xiaju Cheng, Yangyun Wang, Yong Wang*, and Mingyuan Gao*, ACS Nano, 2024, 18, 1022-1040.

10.In vivo clinical molecular imaging of T cell activity, Xiaju Cheng#, Jiahao Shen#, Jingwei Xu*, Jinfeng Zhu, Pei Xu, Yong Wang*, Mingyuan Gao*, Trends Immunol., 2023, 44(12), 1031-1045.

11.Cathepsin K-Activated Probe for Fluoro-Photoacoustic Imaging of Early Osteolytic Metastasis, Zhuorun Song, Jia Miao, Minqian Miao, Baoliang Cheng, Shenhua Li, Yinghua Liu, Qingqing Miao, QingLi*, MingyuanGao*, Adv. Sci., 2023, 10(24), 202300217.

12.A Tumor Microenvironment-Activatable Molecular Pro-theranostic Agent for Photodynamic and Immunotherapy of Cancer, Hui Zhou, Yuan Zhang, Ruru Zhang, Min Zhao, Wan Chen, Yinghua Liu, YueJiang, Qing Li, Qingqing Miao*, Mingyuan Gao*, Adv. Mater., 2023, 35(30), 202211485.

13.Vision for Ratiometric Nanoprobes: In Vivo Noninvasive Visualization and Readout of Physiological Hallmarks, Mohammad Javad Afshari#, Xiaju Cheng#, Guangxin Duan, Ruixue Duan, Shuwang Wu, Jianfeng Zeng, Zi Gu, and Mingyuan Gao*, ACS Nano, 2023, 17(8), 7109-7134.

14.Intranasal Pathway for Nanoparticles to Enter the Central Nervous System, Dandan Kou, Yun Gao, Cang Li, Dandan Zhou, Kuan Lu, Ning Wang, Ruru Zhang, Zhe Yang, Yi Zhou, Lei Chen, Jianxian Ge, Jianfeng Zeng*, Mingyuan Gao*, Nano Lett., 2023, 23(11), 5381-5390.

15.Chemotherapy-Sensitized In Situ Vaccination for Malignant Osteosarcoma Enabled by Bioinspired Calcium Phosphonate Nanoagents, Yangyun Wang#, Yanxian Wu#, Liubing Li#, Chunjie Ma, Shaodian Zhang, Subin Lin, Leshuai W. Zhang, Yong Wang*, Mingyuan Gao*, ACS Nano, 2023, 17(7), 6247-6260.

16.Predicting Thrombolytic Haemorrhage Risk of Acute Ischemic Stroke Through Angiogenesis/Inflammation Dual-targeted MR Imaging, Peisen Zhang#, Yicheng Feng#, Lichong Zhu, Kunyao Xu, Qiuhong Ouyang, Jianfeng Zeng, Feng Qin, Ni Zhang, Yuqing Wang, Fangfei He, Yufang Shi, Gang Chen, Zhe Shi, Meng Qin*, Yi Hou*, Mingyuan Gao*, Nano Today, 2023, 48, 101707.

17.Self-illuminating NIR-II Bioluminescence Imaging Probe Aased on Silver Sulfide Quantum Dots, Mohammad Javad Afshari, Cang Li, Jianfeng Zeng, Jiabin Cui, Shuwang Wu, Mingyuan Gao*, ACS Nano, 2022, 16(10), 16824-16832.

18.Near-Infrared Afterglow Luminescence of Chlorin Nanoparticles for Ultrasensitive In Vivo Imaging, Wan Chen, Yuan Zhang, Qing Li*, Yue Jiang, Hui Zhou, Yinghua Liu, Qingqing Miao*, and Mingyuan Gao*, J. Am. Chem. Soc., 2022, 144, 6719-6726.

19.Two-pronged Intracellular Co-delivery of Antigen and Adjuvant for Synergistic Cancer Immunotherapy, Junli Meng#, Peisen Zhang#, Qizhe Chen, Zihua Wang, Yuan Gu, Jie Ma, Wang Li, Chen Yang, Yuanyuan Qiao, Yi Hou, Lihong Jing, Yong Wang, Zi Gu, Lichong Zhu, Haozhen Xu, Xueguang Lu*, Mingyuan Gao*, Adv. Mater., 2022, 2202168.

20.Peisen Zhang‡, Jianfeng Zeng‡, Yingying Li, Chen Yang, Junli Meng, Yi Hou*, and Mingyuan Gao*. Quantitative Mapping of Glutathione within Intracranial Tumors through Interlocked MRI Signals of a Responsive Nanoprobe. Angew. Chem. Int. Ed., 2021, 60 (15), 8130-8138.

21.Haijie Han‡, Yi Hou‡, Xiaohui Chen‡, Peisen Zhang, Muxing Kang, Qiao Jin*, Jian Ji, and Mingyuan Gao*. Metformin-induced Stromal Depletion to Enhance the Penetration of Gemcitabine-Loaded Magnetic Nanoparticles for Pancreatic Cancer Targeted Therapy. J. Am. Chem. Soc., 2020, 142(10), 4944-4954.

22.Peisen Zhang, Yi Hou*, Jianfeng Zeng, Yingying Li, Zihua Wang, Ran Zhu, Tiancong Ma, and Mingyuan Gao*. Coordinatively Unsaturated Fe3+ Based Activable Probes for Enhanced MRI and Therapy of Tumors. Angew. Chem. Int. Ed., 2019, 58(32), 11088-11096.

23.Xiangzhao Ai, Zhimin Wang, Yong Wang, Ruochong Zhang, Jun Lin, Yuanjing Zheng, Mingyuan Gao*, Bengang Xing*. Multispectral Optoacoustic Imaging of Redox Correlation for Dynamic Profiling of Inflammation Progression. Nat. Comm., 2019, 1087.

24.Tiancong Ma‡, Yi Hou‡, Jianfeng Zeng‡, Chunyan Liu, Peisen Zhang, Lihong Jing, Dihua Shangguan, and Mingyuan Gao*. Dual-Ratiometric Target-Triggered Fluorescent Probe for Simulta-neous Quantitative Visualization of Tumor Microenvironment Pro-tease and pH in vivo. J. Am. Chem. Soc., 2018, 140(1), 211-218.

25.Zhenyu Gao‡, Yi Hou‡, Jianfeng Zeng, Lei Chen, Chunyan Liu, Wensheng Yang*, and Mingyuan Gao*. Tumor Microenvironment-Triggered Aggregation of Anti-Phagocytosis 99mTc-Labelled Fe3O4 Nanoprobes for Enhanced Tumor Imaging in Vivo. Adv. Mater., 2017, 29(24), 1701095.

26.Xiaju Cheng, Rui Sun, Ling Yin, Zhifang Chai, Haibin Shi*, and Mingyuan Gao*. Light-triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo. Adv. Mater., 2017, 29, 1604894.

27.Lihong Jing‡, Stephen V. Kershaw‡, Yilin Li, Xiaodan Huang, Yingying Li, Andrey L. Rogach*, and Mingyuan Gao*. Aqueous Based Semiconductor Nanocrystals. Chem. Rev., 2016, 116(18), 10623-10730.

28.Lihong Jing‡, Stephen V. Kershaw‡, Tobias Kipp‡, Sergii Kalytchuk, Ke Ding, Jianfeng Zeng, Mingxia Jiao, Xiaoyu Sun, Alf Mews, Andrey L. Rogach, and Mingyuan Gao*.  Insight into Strain Effects on Band Alignment Shifts, Carrier Localization and Recombination Kinetics in CdTe/CdS Core/Shell Quantum Dots . J. Am. Chem. Soc., 2015, 137(5), 2073-2084.

29.Jianfeng Zeng, Lihong Jing, Yi Hou, Mingxia Jiao, Ruirui Qiao, Qiaojuan Jia, Chunyan Liu, Fang Fang, Hao Lei, and Mingyuan Gao*.  Anchoring Group Effects of Surface Ligand on Magnetic Properties of Fe3O4 Nanoparticles: Towards High Performance MRI Contrast Agents . Adv. Mater., 2014, 26(17), 2694-2698.