曾剑峰 特聘教授，博士生导师
电子邮箱：jfzeng@suda.edu.cn
通讯地址：苏州工业园区仁爱路199号, 邮编215123
办公电话：0512-65882542
个人简历
曾剑峰，苏州大学放射医学与防护学院特聘教授，国家优秀青年科学基金获得者。2016年获苏州市高等院校、科研院所紧缺高层次人才，2017年获苏州大学优秀青年学者，2019年起任日本国立放射线医学综合研究所的客座研究员、中国医药生物技术协会造影技术分会委员，2021年入选江苏省333高层次人才培养工程（第三层次）。截至目前，主持国家级项目4项、省部级项目4项，在Adv. Mater.、J. Am. Chem. Soc.、Angew. Chem.Int. Ed.、ACS Nano、Biomaterials等学术刊物上发表学术论文90余篇，被引6000多次，申请发明专利20余项。获教育部高等学校科学研究优秀成果奖（科学技术）一等奖（排名第五）、江苏省科学技术奖二等奖（排名第三）、苏州市医学会医学科学技术一等奖（排名第四）。
研究方向：
1.分子影像与纳米医学
2.核医学药物
3.转化医学
科研项目：
1.国家自然科学基金优秀青年基金项目，82222033，纳米分子影像及活体成像，2023.01-2025.12，主持
2.国家自然科学基金面上项目，82172003，易损性动脉粥样硬化斑块的早期预警及动态可视化评估，2022.01-2025.12，主持
3.国家重点研发计划“数字诊疗装备”重点专项课题，2016YFC0101201，高灵敏肿瘤多模态纳米分子影像探针，2016.07-2018.12，主持
4.国家重点研发计划“纳米科技”重点专项，2018YFA0208800，新型纳米氧化铁磁共振造影剂的宏量制备及临床转化研究，2018.05-2023.04，参与（项目PI）
5.国家自然科学基金青年科学基金项目，21503141，高灵敏度化学交换饱和转移磁共振分子影像探针的构建及应用，2016.01-2018.12，主持
6.江苏省高等学校自然科学研究重大项目，20KJA150006，磁共振/核医学双模态纳米分子影像探针应用基础研究，2020.10-2023.09，主持
7.江苏省自然科学基金面上项目，BK20191418，可肾代谢氧化铁纳米磁共振造影剂的设计、合成及应用，2019.07-2022.06，主持
8.苏州市重点产业技术创新项目，SYG202036，新型纳米氧化铁静脉补铁剂开发，2020.07-2023.06，主持
9.中国博士后科学基金第9批特别资助，2016T90489，配位聚合物纳米颗粒诊疗一体化探针的构建及应用，2016.07-2018.06，主持
10.中国博士后科学基金第57批面上资助（一等），2015M570472，高灵敏度智能化磁共振分子影像探针的构建及应用，2015.07-2017.06，主持
11.北京分子科学国家实验室开放课题，20140165，高灵敏度智能化磁共振分子影像探针，2015.01-2016.12，主持
代表性论文：
1.Iron Homeostasis-Regulated Adaptive Metabolism of PEGylated Ultrasmall Iron Oxide Nanoparticles Ning Wang, Dandan Zhou, Keyang Xu, Dandan Kou, Can Chen, Cang Li, Jianxian Ge, Lei Chen, Jianfeng Zeng*, Mingyuan Gao* ACS Nano, 2025, DOI: 10.1021/acsnano.5c01399
2.A Sophisticated Ratiometric Nuclear Medicine Imaging Strategy for Biological Microenvironment Abnormal Factor Detection
Jianxian Ge, Haodi Qi, Lishu Zhao, Xiaoyi Cao, Can Chen, Ruru Zhang, Mohammad Javad Afshari, Yun Gao, Chaoping Sun, Lei Chen, Jianfeng Zeng*, Mingyuan Gao* Adv. Healthc. Mater.,2025, DOI: 10.1002/adhm.202404914
3.Splenic response to protein corona of nanoparticles in vivo
Can Chen, Yueping Li, Dandan Zhou, Jiada Fan, Xuelan Hu, Ruru Zhang, Jianxian Ge, Xiaoyi Cao, Haodi Qi, Ning Wang, Lei Chen, Baoxing Huang, Jianfeng Zeng*, Mingyuan Gao* Nano Today,2025, DOI: 10.1016/j.nantod.2025.102676
4.Glial Cell Crosstalk in Parkinson’s Disease: Mechanisms, Implications, and Therapeutic Strategies Ning Wang#, Xiao Xiao#, Zilu Chen#, Keyang Xu, Xiaoyi Cao, Dandan Kou, Jianfeng Zeng* Fundamental Research,2025, DOI: 10.1016/j.fmre.2024.12.023
5.PEGylated Ultrasmall Iron Oxide Nanoparticles as MRI Contrast Agents for Vascular Imaging and Real-Time Monitoring Kuan Lu#, Ruru Zhang#, Hongzhao Wang, Cang Li, Zhe Yang, Keyang Xu, Xiaoyi Cao, Ning Wang, Wu Cai*, Jianfeng Zeng*, Mingyuan Gao* ACS Nano,2025,19(3), 3519-3530.
6.Noninvasive Immunotyping and Immunotherapy Monitoring of Lung Cancers via Nuclear Imaging of LAG-3 and PD-L1
Lishu Zhao, Jianxian Ge, Ruru Zhang, Hao Wang, Xinyue Liu, Kandi Xu, Yujin Liu, Wencheng Zhao, Wengang Zhang, Li Ye, Zhimin Chen, Jianfeng Zeng*, Yayi He*, Mingyuan Gao
Adv. Sci., 2025,12, 202404231.
7.Using Adaptive Imaging Parameters to Improve PEGylated Ultrasmall Iron Oxide Nanoparticles-Enhanced Magnetic Resonance Angiography Cang Li#, Shanshan Shan#, Lei Chen, Mohammad Javad Afshari, Hongzhao Wang, Kuan Lu, Dandan Kou, Ning Wang, Yang Gao, Chunyi Liu, Jianfeng Zeng*, Feng Liu, Mingyuan Gao*Adv. Sci., 2024,11, 202405719.
8.Trapped in Endosome PEGylated Ultra-Small Iron Oxide Nanoparticles Enable Extraordinarily High MR Imaging Contrast for Hepatocellular Carcinomas Dandan Zhou, Shanshan Shan, Lei Chen, Cang Li, Hongzhao Wang, Kuan Lu, Jianxian Ge, Ning Wang, Mohammad Javad Afshari, Yaqin Zhang*, Jianfeng Zeng*, Mingyuan Gao* Adv. Sci., 2024,11, 202401351.
9.Unveiling the Biologically Dynamic Degradation of Iron Oxide Nanoparticles via a Continuous Flow System Zhe Yang#, Shuwang Wu#, Yun Gao, Dandan Kou, Kuan Lu, Can Chen, Yi Zhou, Dandan Zhou, Lei Chen, Jianxian Ge, Cang Li, Jianfeng Zeng,* Mingyuan Gao* Small Methods,2024,8(3), 2301479.
10.Surface ligand-regulated renal clearance of MRI/SPECT dual-modality nanoprobes for tumor imaging Can Chen#, Baoxing Huang#, Ruru Zhang, Chaoping Sun, Lei Chen, Jianxian Ge, Dandan Zhou, Yueping Li, Shuwang Wu, Zhiyuan Qian, Jianfeng Zeng*, Mingyuan Gao* J. Nanobiotechnol.,2024,22, 245.
11.Clinically Translatable Phosphonated Silica Microspheres for Selective Internal Radiation Therapy of Hepatocellular Carcinoma
Yi Zhou, Jianxian Ge, Yun Gao, Zhe Yang, Mohammad Javad Afshari, Can Chen, Manran Wu, Lei Chen, Shuwang Wu*, Guangxin Duan, Jianfeng Zeng*, Mingyuan Gao* Small Sci.,2023,3(10), 2300035.
12.Biomimetic Upconversion Nanoplatform Synergizes Photodynamic Therapy and Enhanced Radiotherapy against Tumor Metastasis Dandan Zhou, Yun Gao, Zhe Yang, Ning Wang, Jianxian Ge, Xiaoyi Cao, Dandan Kou, Yuan Gu, Cang Li, Mohammad Javad Afshari, Ruru Zhang, Can Chen, Ling Wen*, Shuwang Wu, Jianfeng Zeng*, Mingyuan Gao ACS Appl. Mater. Interfaces,2023,15(22), 26431-26441.
13.Reversing Acute Kidney Injury Through Coordinated Interplay of Anti-inflammation and Iron Supplementation Ruixue Duan#*, Yueping Li#, Ruru Zhang, Xuelan Hu, Yi wang, Jianfeng Zeng*, Mingyuan Gao* Adv. Mater.,2023,35(28), 2301283.
14.Intranasal Pathway for Nanoparticles to Enter the Central Nervous System Dandan Kou, Yun Gao, Cang Li, Dandan Zhou, Kuan Lu, Ning Wang, Ruru Zhang, Zhe Yang, Yi Zhou, Lei Chen, Jianxian Ge, Jianfeng Zeng*, Mingyuan Gao* Nano Lett.,2023,23(11), 5381-5390.
15.An APN‐Activated Chemiluminescent Probe for Image‐Guided Surgery of Malignant Tumors Yinghua Liu#, Jianfeng Zeng#, Qing Li*, Minqian Miao, Zhuorun Song, Min Zhao, Qingqing Miao*, Mingyuan Gao* Adv. Opt. Mater.,2022, 202102709.
16.Anchoring Group Mediated Radiolabeling of Inorganic Nanoparticles - A Universal Method for Constructing Nuclear Medicine Imaging Nanoprobes Jianxian Ge, Lei Chen, Baoxing Huang, Yun Gao, Dandan Zhou, Yi Zhou, Can Chen, Ling Wen, Qing Li, Jianfeng Zeng*, Zhiyuan Zhong, and Mingyuan Gao* ACS Appl. Mater. Interfaces, 2022, 14(7), 8838-8846.
17.Ultrasmall Superparamagnetic Iron Oxide Nanoparticles: A Next Generation Contrast Agent for Magnetic Resonance Imaging
Can Chen#, Jianxian Ge#, Yun Gao, Lei Chen, Jiabin Cui, Jianfeng Zeng*, and Mingyuan Gao*WIREs Nanomed. Nanobi.,2022, e1740.
18.Cell-Derived Biomimetic 2D Nanoparticles to Improve CellSpecific Targeting and Tissue Penetration for Enhanced Magnetic Resonance Imaging Qianyi Zhang#, Dandan Zhou#, Guocheng Fang, Hongxu Lu, Jianfeng Zeng*, and Zi Gu* Adv. Mater.Interfaces, 2021, 202101914.
19.Anchoring Group Mediated Radiolabeling for Achieving Robust Nano-Imaging Probes Lei Chen, Jianxian Ge, Baoxing Huang, Dandan Zhou, Gang Huang, Jianfeng Zeng*, and Mingyuan Gao Small,2021,202104977.
20.Quantitative Mapping of Glutathione within Intracranial Tumors through Interlocked MRI Signals of a Responsive Nanoprobe
Peisen Zhang#, Jianfeng Zeng#, Yingying Li, Chen Yang, Junli Meng, Yi Hou,* and Mingyuan Gao* Angew. Chem. Int. Ed.,2021, 60(15), 8130-8138.
21.Radiolabeling nanomaterials for multimodality imaging: New insights into nuclear medicine and cancer diagnosis Jianxian Ge, Qianyi Zhang,Jianfeng Zeng*, Zi Gu*, Mingyuan Gao Biomaterials, 2020, 228, 119553.
22.Self-Assembled Hybrid Nanocomposites for Multimodal Imaging-Guided Photothermal Therapy of Lymph Node Metastasis
Wu Cai#, Guohua Fan#, Hui Zhou#, Lei Chen, Jianxian Ge, Baoxing Huang, Dandan Zhou, Jianfeng Zeng,* Qingqing Miao,* and Chunhong Hu* ACS Appl. Mater. Interfaces,2020, 12(44), 49407-49415.
23.A Dual-Modal Molecular Probe for Near-Infrared Fluorescence and Photoacoustic Imaging of Peroxynitrite Jianjian Zhang, Xu Zhen, Jianfeng Zeng*, and Kanyi Pu* Anal. Chem.,2018, 90(15), 9301-9307.
24.Dual-Ratiometric Target-Triggered Fluorescent Probe for Simultaneous Quantitative Visualization of Tumor Microenvironment Protease Activity and pH in vivo Tiancong Ma#, Yi Hou#, Jianfeng Zeng#, Chunyan Liu, Peisen Zhang, Lihong Jing, Dihua Shangguan, and Mingyuan Gao* J. Am. Chem. Soc., 2018,140(1), 211-218.
25.Enhancing Both Biodegradability and Efficacy of Semiconducting Polymer Nanoparticles for Photoacoustic Imaging and Photothermal Therapy Yan Lyu#, Jianfeng Zeng#, Yuyan Jiang, Xu Zhen, Ting Wang, Shanshan Qiu, Xin Lou*, Mingyuan Gao, Kanyi Pu* ACS Nano,2018,12(2), 1801-1810.
26.Biodegradable Nano-agents with Short Biological Half-life for SPECT/PAI/MRI Multimodality Imaging and PTT Therapy of Tumors Lei Chen#, Jaiyao Chen#, Shanshan Qiu, Ling Wen, Yan Wu, Yi Hou, Yong Wang, Jianfeng Zeng*, Yuan Feng, Zhen Li, Hong Shan*, and Mingyuan Gao* Small,2018,14(4), 1702700.
27.pH-Responsive Fe(III)-Gallic-Acid Nanoparticles for In-Vivo Photoacoustic Imaging Guided Photothermal Therapy Jianfeng Zeng#, Ming Cheng#, Yong Wang, Ling Wen, Ling Chen, Zhen Li*, Yongyou Wu*, Mingyuan Gao*, Zhifang Chai Adv. Healthc. Mater.,2016,5(7), 772-780.
28.A Self-Assembled Albumin-Based Nanoprobe for In Vivo Ratiometric Photoacoustic pH Imaging Qian Chen, Xiaodong Liu, Jiawen Chen, Jianfeng Zeng*, Zhenping Cheng, Zhuang Liu* Adv. Mater.,2015, 27(43), 6820–6827.
29.Anchoring Group Effects of Surface Ligand on Magnetic Properties of Fe3O4 Nanoparticles: Towards High Performance MRI Contrast Agents Jianfeng Zeng, Lihong Jing, Yi Hou, Mingxia Jiao, Ruirui Qiao, Qiaojuan Jia, Chunyan Liu, Fang Fang, Hao Lei, Mingyuan Gao* Adv. Mater.,2014,26(17), 2694-2698.
30.In Situ 111In-doping for Achieving Biocompatible and Non-leachable111In-labeled Fe3O4 Nanoparticles Jianfeng Zeng, Bing Jia, Ruirui Qiao, Chao Wang, Lihong Jing, Fan Wang Mingyuan Gao* Chem. Commun.,2014, 50(17), 2170-2172.