徐鹏，特聘教授，博士生导师

苏州大学苏州医学院唐仲英医学研究院血液学研究中心

苏州大学放射医学与辐射防护国家重点实验室

苏州工业园区仁爱路199号703号楼3625室；邮编：215123

邮箱：pengxu@suda.edu.cn

教育经历：

2006年~2010年 中南大学生物技术专业理学学士

2010年~2015年 北京协和医学院生物化学与分子生物学专业理学博士，导师刘德培院士

2015年~2020年 美国圣裘德儿童研究医院血液学博士后，合作导师Mitchell J. Weiss教授

工作经历：

2020年~至今 苏州大学苏州医学院唐仲英血液学研究中心

苏州大学放射医学与辐射防护国家重点实验室

2024年~至今 苏州大学附属第一医院 “双聘教授”

研究方向：

实验室长期规划：面向国家重大临床需求，以重大科学问题为导向，建立一个以研究造血发育调控与恶性血液疾病为核心的基础研究和临床转化相结合的研究室。实验室主要利用基因编辑和高通量筛选技术结合多组学大数据整合研究手段，致力于解析造血调控新机制，鉴定血液系统疾病新靶点。目前主要研究方向包括：1.造血发育调控与恶性血液肿瘤的全新分子调控机制。2.造血系统辐照损伤与修复重建的分子机理与干预研究。

承担/参与项目：

1.国家重点研发计划重点专项子课题；2022-2025；学术骨干参与

2.国家自然科学基金面上项目；2022-2025；主持

3.江苏省江苏特聘教授，2023-2025，主持

4.江苏省“双创”团队成员，2024-2026

5.江苏省青年基金项目；2020-2024；主持

6.苏州市姑苏青年领军人才创新类项目；2021-2024；主持

7.苏州市科协青年科技人才托举工程项目；2021-2022，主持

8.江苏省基础研究计划重点项目；2024-2027，学术骨干参与

9.苏州市级重点项目苏州医学院青年培育项目，2023-2025，主持

发表论文：

(#equalcontribution *correspondingauthor)

近5年内发表的5篇代表性论著

1.Peng Xu; Daniel C. Scott; Beisi Xu; Yu Yao; Ruopeng Feng; Li Cheng; Kalin Mayberry; Yong-Dong Wang; Wenjian Bi; Lance E. Palmer;MoekoT. King; Hong Wang; Yuxin Li; Yiping Fan; Arno F. Alpi; Chunliang Li; Junmin Peng; James Papizan; Shondra M. Pruett-Miller; Ria Spallek; Florian Bassermann; Yong Cheng; Brenda A. Schulman; Mitchell J. Weiss*; FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis, Blood, 2021, 137(2): 155-167. (Plenary Article)

2.Xue Yang^#, Li Cheng^#, Ye Xin^#, Jianxiang Zhang^#, Xinfeng Chen, Jinchao Xu, Mengli Zhang, Ruopeng Feng, Judith Hyle, Wenjie Qi,Wojciech Rosikiewicz, Beisi Xu*, Chunliang Li*andPengXu*. CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis. Genome Biology. 2025,26:44

3.Mengli Zhang, Judith Hyle, Xiaowen Chen, Ye Xin, Yingcai Jin, Jianxiang Zhang, Xue Yang, Xinfeng Chen, Shaela Wright, Zhenling Liu, Wojciech Rosikiewicz, Beisi Xu, Liusheng He, Hong Liu, Nana Ping, Depei Wu, Feiqiu Wen, Chunliang Li*,Peng Xu*;RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9, Genome Biology, 2024, 25:16

4.Congwen Shao#,Qing Liu#,Jinchao Xu#,Jianxiang Zhang, Chengpeng Zhang, Ye Xin,Yuhua Ye,Bin Lin, Xinhua Zhang, Li Cheng*,Xiangmin Xu*,andPengXu*, Efficient and in situ correction of hemoglobin Constant Spring mutation by prime editing in human hematopoietic cells, Molecular Therapy Nucleic Acids, 2024, 35(4):102371

5.Ozge Karayel#;Peng Xu#; Isabell Bludau; Senthil Velan Bhoopalan; Yu Yao; Ana Rita Freitas Colaco; Alberto Santos; Brenda A Schulman*; Arno F Alpi*; Mitchell J Weiss*; Matthias Mann*; Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis, Molecular Systems Biology, 2020, 16(e9813).

近5年内发表的其他论著

6.Mengli Zhang #;Mei Meng#;Yuxi Liu;Jindan;Zhe Zhao;Yingnan Qiao;Yanxing Hu;Wei Lu;Zhou Zhou;Peng Xu*;Quansheng Zhou*; Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins, Breast Cancer Research, 2021,23:116.

7.Chengpeng Zhang#, Jinchao Xu#, Yikang Wu, Can Xu,Peng Xu*; Base Editors Mediated Gene Therapy in Hematopoietic Stem Cells for Hematologic Diseases, Stem Cell Reviews and Reports, 2024,(6):1387-1405 (Review)

8.Dawafuti Sherpa#, Judith Müller#, Özge Karayel#,Peng Xu#, Yu Yao, Jakub Chrustowicz, Karthik V. Gottemukkala, Christine Baumann, Annette Gross, Oliver Czarnezki, Wei Zhang, Jun Gu, Johan Nilvebrant, Sachdev S. Sidhu, Peter J. Murray, Matthias Mann, Mitchell J. Weiss, Brenda A. Schulman, Arno F. Alpi*; Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation, eLife, 2022, 11:e77937.

9.Ruopeng Feng, Thiyagaraj Mayuranathan, Peng Huang , Phillip A Doerfler, Yichao Li, Yu Yao, Jingjing Zhang, Lance E Palmer, Kalin Mayberry, Georgios E Christakopoulos, Peng Xu, Chunliang Li, Yong Cheng, Gerd A Blobel, M Celeste Simon, Mitchell J Weiss*; Activation of γ-globin expression by hypoxia-inducible factor 1α, Nature, 2022, 610(7933):783-790.

10.Li Cheng#; Yichao Li#; Qian Qi;Peng Xu; Ruopeng Feng; Lance Palmer; Jingjing Chen; Ruiqiong Wu; Tiffany Yee; Jingjing Zhang; Yu Yao; Akshay Sharma; Ross C. Hardison; Mitchell J. Weiss*; Yong Cheng*; Single-nucleotide–level mapping of DNA regulatory elements that control fetal hemoglobin expression,Nature Genetics, 2021,53(6):869-880.

11.Xiaoqiang Tang#; Xiao-Feng Chen#; Xin Sun#;Peng Xu; Xiang Zhao; Ying Tong; Xiao-Man Wang; Ke Yang; Yu-Tong Zhu; De-Long Hao; Zhu-Qin Zhang; De-Pei Liu*; Hou-Zao Chen*; Short-Chain Enoyl-CoA Hydratase Mediates Histone Crotonylation and Contributes to Cardiac Homeostasis, Circulation, 2021, 143(10): 1066-1069.

12.Qian Qi#; Li Cheng#; Xing Tang; Yanghua He; Yichao Li; Tiffany Yee; Dewan Shrestha; RuopengFeng;Peng Xu; Xin Zhou; Shondra Pruett-Miller; Ross C. Hardison; Mitchell J. Weiss; Yong Cheng*; Dynamic CTCF binding directly mediates interactions among cis-regulatory elements essential for hematopoiesis, Blood, 2021, 137(10): 1327-1339.

13.Yao Yao#; Fei Ye#; Kailong Li;Peng Xu; Wenjie Tan; Quansheng Feng; Shuquan Rao*; Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21.31 locus associated with severe COVID-19. Signal Transduct Target Ther.,2021,6(1):85.

14.Xiuqin Bao#; Xinhua Zhang#; Liren Wang; Zhongju Wang; Jin Huang; Qianqian Zhang; Yuhua Ye; Yongqiong Liu; Diyu Chen; Yangjin Zuo; Qifa Liu;Peng Xu; Binbin Huang; Jianpei Fang; Jinquan Lao; Xiaoqin Feng; Yafeng Li; Ryo Kurita; Yukio Nakamura; Weiwei Yu; Cunxiang Ju; Chunbo Huang; Narla Mohandas; Dali Li; Cunyou Zhao*; Xiangmin Xu*; Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia, The American Journal of Human Genetics, 2021, 108(4): 709-721.

5年以外的代表性论著

15.Peng Xu#; Lance E. Palmer#; ChristopheLechauve; Guowei Zhao; Yu Yao; Jing Luan; Anastasios Vourekas; Haiyan Tan; JunminPeng; John D. Schuetz; Zissimos Mourelatos; Gang Wu; Mitchell J. Weiss*; Vikram R. Paralkar*; Regulation of gene expression by miR-144/451 during mouse erythropoiesis, Blood, 2019, 133(23): 2518-2528.

16.Peng Xu#; Ting-ting Wang#; Xiu-zhen Liu#; Nan-Yu Wang; Li-hong Sun; Zhu-qin Zhang; Hou-zao Chen; Xiang Lv; Yue Huang; De-Pei Liu*; Sirt6 regulates efficiency of mouse somatic reprogramming and maintenance of pluripotency, Stem Cell Research & Therapy, 2019, 10(9).

17.Judith Hyle#; Yang Zhang#; Shaela Wright; Beisi Xu; Ying Shao; John Easton; Liqing Tian; RuopengFeng;Peng Xu; Chunliang Li*; Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping, Nucleic Acids Research, 2019, 47(13): 6699-6713.

18.Xiao Fang#; Feiyang Shen#; Christophe Lechauve;Peng Xu; Guowei Zhao; Jacobi Itkow; Fan Wu; Yaying Hou; Xiaohui Wu; Lingling Yu; Huiqing Xiu; Mengli Wang; Ruiling Zhang; Fangfang Wang; Yanqing Zhang; Daxin Wang; Mitchell J. Weiss; Duonan Yu*; miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia, Haematologica, 2018, 103(3): 406-416.

19.Wen-Li Mu#; Ya-Jun Wang#;Peng Xu#; De-Long Hao; Xiu-Zhen Liu; Ting-Ting Wang; Feng Chen; Hou-Zao Chen; Xiang Lv; De-Pei Liu*; Sox2 Deacetylation by Sirt1 Is Involved in Mouse Somatic Reprogramming, Stem Cells, 2015, 33(7): 2135-2147.

20.Peng Xu#; Ying Tong#; Xiu-zhen Liu; Ting-ting Wang; Li Cheng; Bo-yu Wang; Xiang Lv; Yue Huang; De-pei Liu*; Both TALENs and CRISPR/Cas9 directly target the HBB IVS2–654 (C > T) mutation in β-thalassemia derived iPSCs, Scientific Reports, 2015, 5(12065).

团队成员：

科研助理：杨雪

博士后：张梦利

在读研究生：张建祥（2022级博士研究生）、辛晔（2023级博士研究生）、陈新凤（2022级硕士研究生）、李旭 （2022级硕士研究生）、宋笑笑 （2022级硕士研究生）、周欢（2022级硕士研究生）、邢媛（2023级硕士研究生）、欧阳雨欣（2023级硕士研究生）、刘清（南方医科大学联合培养）

往届毕业生及去向：邵聪文（2019级博士研究生，南方医科大学联合培养），南方医科大学深圳医院；辛晔（2020级硕士），在读博士研究生；张梦利（2021级），在站博士后；徐进超（2021级），创盛（广州）医药有限公司；金英才（2021级），中国刑警学院

实验室文化：“严谨，求实，快乐，平等”

招生专业：生物学-生物化学与分子生物学

诚邀有志有科研激情、扎实阳光的青年“后浪”加盟，为苏州大学放射医学与辐射防护国家重点实验室的发展贡献力量！ 

实验室网站: https://www.x- mol.com/groups/pengxu_lab